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Proteomics Laboratory
Principle Investigator: Cheng, Yu-Che, Ph.D.

 

Current Affiliation

Research Fellow, Cathay Medical Research Institute
No. 32, Ln. 160, Jiancheng Rd., Xizhi Dist., New Taipei City, 22174, Taiwan
Tel: +886-26907965-2615, Fax: +886-26907963
E-mail: yccheng@cgh.org.tw

Adjunct Associate Professor
Department of Biomedical Science and Engineering
National Central University, Jhongli Dist., Taoyuan City, Taiwan

 

Education

07/2006 Ph.D., Graduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University

07/1997 M.S., Graduate Institute of Agriculture Chemistry, National Taiwan University

06/1995 B.S., Department of Agriculture Chemistry, National Taiwan University

 

Professional Interests

Protein chemistry, Mass spectrometry and Mechanobiology

 

Professional Experience

2006 - present    Research Fellow, Cathay Medical Research Institute

2010 - 2018    Adjunct Assistant Professor, Graduate Institute of Biomedical Engineering

2018 - present    Adjunct Associate Professor, Department of Biomedical Science and Engineering

2003-2006    Operator, ESI-LC-MS/MS, Protein Core Lab, College of Medicine, National Taiwan University

2003-2006    Research Assistant, Program for Promotion Academic Excellence of Universities

2005-2013    Lecturer, Course of Proteomics, College of Bioresource, National ILan University

Honors / Awards

2006    Excellent paper award of the year, College of Medicine, National Taiwan University

 

Publications(2016-2022)

  1. Yu-Che Cheng*, Chi-Jung Huang, Yih-Jing Lee, Lu-Tai Tien, Wei-Chi Ku, Raymond Chien, Fa-Kung Lee and Chih-Cheng Chien. Knocking down of Heat-shock Protein 27 directs differentiation of functional glutamatergic neurons from Placenta-derived Multipotent Cells. Sci. Rep. 2016, 6, 30314; doi: 10.1038/srep30314 (IF: 4.996, #19/73, MULTIDISCIPLINARY SCIENCES, 2021) (*Co-1st author)
  2. Chih-Cheng Chien, Chi-Jung Huang, Lu-Tai Tien, Yu-Che Cheng, Chia-Ying Ke, Yih-Jing Lee. Suppression of HSP27 Restores Retinal Function and Protects Photoreceptors From Apoptosis in a Light-Induced Retinal Degeneration Animal Model. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3107-3117. doi: 10.1167/iovs.16-21007. (IF: 4.925, #10/61, OPHTHALMOLOGY, 2021)
  3. Sheng-Yuan Huang, Chih-Cheng Chien, Ruey-Shyang Hseu, Victoria Ying Jen Huang, Shang Ying Chiang, Chi-Jung Huang, Shao-Kuan Chen, Ru-Yin Tsai, Hsi-Ting Lin, Yu Che Cheng*. Ganoderma microsporum immunomodulatory protein induces apoptosis and potentiates mitomycin C-induced apoptosis in urinary bladder urothelial carcinoma cells. 2018 Jun;119(6):4592-4606. doi: 10.1002/jcb.26616. (IF: 4.480, #136/296, BIOCHEMISTRY & MILECULAR BIOLOGY, 2021) (*Correspondence)
  4. Yu-Hsiang Lee, Chia-Wei Lai, Yu Che Cheng*. Fluid Shear Stress Induces Cell Cycle Arrest in Human Urinary Bladder Transitional Cell Carcinoma Through Bone Morphogenetic Protein Receptor-Smad1/5 Pathway. Cel. Mol. Bioeng. 2018 June, Vol. 11 (3), pp. 185–195 doi: 10.1007/s12195-018-0523-1 (IF: 3.337, #59/98, ENGINEERING, BIOMEDICAL, 2021) (*Co-Correspondence)
  5. Wei-Wen Hu, Tun-Chi Chen, Chia-Wen Tsao, and Yu-Che Cheng*. The effects of substrate-mediated electrical stimulation on the promotion of osteogenic differentiation and its optimization. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2019 Jul;107(5):1607-1619. doi: 10.1002/jbm.b.34253.  (IF: 3.405, #58/98, ENGINEERING, BIOMEDICAL, 2021) (*Co-Correspondence)
  6. Yu-Che Cheng*, Ru-Yin Tsai, Yen-Tseng Sung, Ing-Jung Chen, Tzu-Yi Tu, Ya-Yuan Mao, and Chih-Shung Wong. Melatonin regulation of transcription in the reversal of morphine tolerance: Microarray analysis of differential gene expression. International Journal of Molecular Medicine. Vol. 43: pp.791-806, 2019, doi: 10.3892/ijmm.2018.4030. (IF:5.314, #59/335, BIOCHEMISTRY, GENETICS AND MOLECULAR BIOLOGY, 2021) (*Co-1st author)
  7. Yu-Che Cheng*, Chien-Hsun Chen, Hong-Wei Kuo, Ting-Ling Yen, Ya-Yuan Mao, and Wei-Wen Hu. Electrical Stimulation through Conductive Substrate to Enhance Osteo-Differentiation of Human Dental Pulp-Derived Stem Cells. Appl. Sci. 2019, 9, 3938; doi:10.3390/app9183938. (IF: 2.838, #38/92, ENGINEERING, MULTIDISCIPLINARY, 2021) (*Co-1st author)
  8. Yu-Che Cheng*, Shu-Lin Guo, Kun-Da Chung and Wei-Wen Hu. Electrical Field-Assisted Gene Delivery from Polyelectrolyte Multilayers. Polymers 2020, 12, 133; doi:10.3390/polym12010133. (IF: 4.967, #15/90, POLYMER SCIENCE, 2021) (*Co-1st author)
  9. Yu-Che Cheng*, Wei-Chi Ku, Ting-Ting Tseng, Ching-Po Wu, Meng-Jin Li, Shao-Chen Lee. Anchorage independence altered vasculogenic phenotype of melanoma cells through downregulation in aminopeptidase N /syndecan-1/integrin β4 axis. Aging (Albany NY). 2020 Aug 4;12(17):16803-16819. doi: 10.18632/aging.103425. (IF: 5.922, #72/194, CELL BIOLOGY, 2021) (*1st author)
  10. Chia-Yu Shih and Yu-Che Cheng*, Chiao-Hui Hsieh, Ting-Ting Tseng, Shih-Sheng Jiang, Shao-Chen Lee. Drug-selected population in melanoma A2058 cells as melanoma stem-like cells retained angiogenic features – the potential roles of heparan-sulfate binding ANGPTL4 protein. Aging (Albany NY). 2020 Nov 10; 12(22):22700-22718. doi: 10.18632/aging.103890. (IF: 5.922, #72/194, CELL BIOLOGY, 2021) (*Co-1st author)
  11. Wen-Chin Ko, Chia-Ti Tsai, Kai-Cheng Hsu, Yu-Che Cheng, Tony Eight Lin, Yi-Ling Chen, Chuang-Ye Hong, Wan-Jung Lu, Chun-Ming Shih and Ting-Lin Yen. Magnolol, A Novel Antagonist of Thrombin and PAR-1, Inhibits Thrombin-Induced Connective Tissue Growth Factor (CTGF) Expression in Vascular Smooth Muscle Cells and Ameliorate Pathogenesis of Restenosis in Rats. Appl. Sci. 2020, 10(23), 8729; https://doi.org/10.3390/app10238729 - 05 Dec 2020. (IF: 2.838, #38/92, ENGINEERING, MULTIDISCIPLINARY, 2021)
  12. Shih-Feng Wang, Yun-Chung Wu, Yu-Che Cheng* and Wei-Wen Hu*. The Development of Polylactic Acid/Multi-Wall Carbon Nanotubes/Polyethylene Glycol Scaffolds for Bone Tissue Regeneration Application. Polymers (Basel), 2021 May 26;13(11):1740. doi: 10.3390/polym13111740. (IF: 4.967, #15/90, POLYMER SCIENCE, 2021) (*Co-Correspondence)
  13. Hsun Chiang, Yu-Che Cheng and Chih-Ang Chung. Endothelial Cell Morphogenesis and Capillary-like Network Induced by Soluble and Bound VEGF in a Definite Biogel Composed of Collagen and Fibronectin. Appl. Sci. 2021, 11(20), 9501; https://doi.org/10.3390/app11209501. (IF: 2.838, #38/92, ENGINEERING, MULTIDISCIPLINARY, 2021)
  14. Chia-Wen Tsao, You-Shan Zheng, Ya-Sen Sun, Yu-Che Cheng. Surface-enhanced Raman scattering (SERS) spectroscopy on localized silver nanoparticle-decorated porous silicon substrate. Analyst. 2021, Nov 22. doi: 10.1039/d1an01708j. (IF: 5.227, #18/87, CHEMISTRY, ANALYTICAL, 2021)
  15. Yu-Che Cheng*, Chi-Jung Huang, Wei-Chi Ku, Shu-Lin Guo, Lu-Tai Tien, Yih-Jing Lee, Chih-Cheng Chien. Downregulated calcium-binding protein S100A16 and HSP27 in placenta-derived multipotent cells induce functional astrocyte differentiation. Stem Cell Reviews and Reports. Feb;18(2):839-852. doi: 10.1007/s12015-021-10319-3. (IF: 6.692, #34/140, MEDICINE, RESEARCH & EXPERIMENTAL, 2021) (*1st author)

 

Grants

2014 –2015 NSC 103-2320-B-281-001- (PI), NTD: 1,173,000

2017 – 2020 MOST 106-2314-B-281-002-MY3 (Co-PI), NTD 4,436,000

2017 –2020 MOST 107-2314-B-281-001-MY3 (PI), NTD: 4,055,000

2018 –2020 MOST 108-2221-E-008-028-MY2- (Co-PI), NTD: 2,070,000

2020 –2023 MOST 109-2314-B-281-002-MY3 (Co-PI), NTD: 4,155,000

2022 –2023 NSTC 111-2314-B-281-002- (PI), NTD: 1,046,000


更新時間:2023/3/2