English

Jiun-Wen, Guo Ph. D.

Researcher

Department of Medical Research, Cathay General Hospital
No. 32, Lane 160, Jian-Cheng Rd., Sijhih Dist., New Taipei City, Taiwan
Phone: +886-2-8646-1500 Ext. 2327 Fax: +886-2-2690-7963
Email: cgh393831@cgh.org.rw

Academic Teaching Ranking

2018 Assistant Professor REG. No. 147278

Education

2014 Ph. D. National Cheng Kung University, Tainan, Taiwan

Honors

2011 Bronze Award, National Chung Kung University Hospital Annual Project
2010 Best presentation Award, First Annual Meeting of Asian-Pacific Barrier Research Society.

Patents

2022   I769745, Taiwan R.O.C
I763071, Taiwan R.O.C
2021   I722775, Taiwan R.O.C
2020   I701046, Taiwan R.O.C

Statement of Research

Current research focuses on developing skin barrier repaired therapy formulations for skin care purposes and pharmaceutical topical delivery formulations followed by 505(b)(2) new drug application regulation to treat inflammatory skin diseases, hemangiomas, skin cancers (BCC and SCC), and melanoma.

Scientific interests (keywords)

Skin barrier, inflammatory skin diseases, topical drug delivery system

PUBLICATIONS

Chen LC, Cheng YP, Liu CY, Guo JW*. Lithosepermic Acid Restored the Skin Barrier Functions in the Imiquimod‐Induced Psoriasis‐like Animal Model. Int J Mol Sci. 2022, 23(11):6172.
Guo JW* and Jee SH. Strategies to develop a suitable formulation for inflammatory skin disease treatment. Int. J. Mol. Sci. 2021, 22(11), 6078.
Guo JW, Cheng YP, Liu CY, Thong HY, Lo Y, Wu CY, Jee SH. Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis‑like dermatitis animal model via the downregulation of interleukin‑23. Experimental and Therapeutic Medicine. 2021 21(5):448.
Guo JW, PU CM, Liu CY, Lo SL, Yen YH. Curcumin loaded self-microemulsifying gel for enhancing wound closure. Skin pharmacology and physiology. 2020 33(6):300-308.
Guo JW, Chien CC, Chen JH. CYP3A Excipient-Based Microemulsion Prolongs the Effect of Magnolol on Ischemia Stroke Rats. Pharmaceutics. 2020, 12(8):737.
Guo JW, Cheng YP, Liu CY, Thong HY, Huang CJ, Lo Y, Wu CY, Jee SH. Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-Induced Psoriasis-Like Dermatitis in Mice. Pharmaceutics. 2020, 12(5):457.
Hung CS, Wang YC, Guo JW, Yang RN, Lee CL, Shen MH, Huang CC, Huang CJ, Yang JY, Liu CY. Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer. Mol Med Rep. 2020 21(2):659-666.
Huang CC, Shen MH, Chen SK, Yang SH, Liu CY, Guo JW, Chang KW, Huang CJ. Gut butyrate-producing organisms correlate to Placenta Specific 8 protein: Importance to colorectal cancer progression. J Adv Res. 2020 22:7-20.
Chee SY, Guo JW, Huang CJ, Chien YH, Lee YC, Feng WK. Rare Concurrence of Two Congenital Disorders: Miller-Dieker Syndrome and T-Cell Lymphopenia. Cytogenetic and Genome Research. 2019;157(4):227-230.
Lin HT, Chen SK, Guo JW, Su IC, Huang CJ, Chien CC, Chang CJ. Dynamic expression of SMAD3 is critical in osteoblast differentiation of PDMCs. Int J Mol Sci. 2019, 43(2):1085-1093.
Guo JW, Lin TK, Wu CH, Wei KC, Lan CC, Peng AC, Tsai JC, Sheu HM. Human sebum extract induces barrier disruption and cytokine expression in murine epidermis. J Dermatol Sci. 2015. 78(1):34-43.
Guo JW, Lee YH, Tsai CH, Hsu LF, Wang YJ, Tsai JC: International considerations for regulating nanotechnology-based pharmaceuticals and development of Taiwan’s strategies. International Journal of Nanomedicine. 2014;9(1):4377-4387.
Tsai JC, Lu CC, Lin MK, Guo JW, Sheu HM: Effects of sebum on drug transport across the human stratum corneum in vivo. Skin pharmacology and physiology 25: 124-132, 2012.
Cheng H, Fu YS, Guo JW. Ability of GDNF to diminish free radical production leads to protection against kainate-induced excitotoxicity in hippocampus. Hippocampus. 2004;14(1):77-86.

Conferences:

Guo JW, Cheng YP, Jee SH. Enhanced the anti-psoriatic effect of desoximetasone by inhibiting cytochrome P450 3A4 metabolism. 2021 Taiwanese Society for Investigative Dermatology (TSID) 16th Annual Meeting.
Guo JW, PU CM, Liu CY, Lo SL, Yen YU. Curcumin loaded microemulsifying gel accelerates wound closure. 2020 Taiwanese Society for Investigative Dermatology (TSID) 15th Annual Meeting.
Guo JW, Cheng YP, Lo Y, Wu CY, Jee SH.The effect of magnolol on the TNF-a/IL-23/Th-17 axis of the imiquimod induced psoriasis-like dermatitis mice. Journal of Investigative Dermatology 198: S23, 2020. Society for Investigative Dermatology (SID) Annual Meeting.
Guo JW, Cheng YP, Liu CY, Lo Y, Wu CY, Jee SH. IL-17 but not IL-23 plays a critical role in the psoriasis. 2019 Taiwanese Society for Investigative Dermatology (TSID) 14th Annual Meeting.
Guo JW, Cheng YP, Jee SH. Exploring the effect of magnolol microemulsion on the treatment of psoriasis from the perspective of skin barrier. 2018 Taiwanese Society for Investigative Dermatology (TSID) 13th Annual Meeting.
Guo JW, Lin TK, Wei KC, Tsai JC, Sheu HM: Fatty acid profile of sebum in seborrheic dermatitis. Journal of Investigative Dermatology 134: S61, 2014. Society for Investigative Dermatology (SID) Annual Meeting.
Guo JW, Chang WY, Tsai JC, Sheu HM: Human Sebum Extract Induces Barrier Disruption and Cytokine Expression in Murine Epidermis. First Annual Meeting of Asian-Pacific Barrier Research Society. 2010.
Wu RM, Guo JW. The Effect of Manganese on Dopamine Release and Hydroxyl Radical Formation in the Striatum of Rat. 1998 Soc. Neuroscience, Abst. 575.1
Wu RM, Guo JW. The Effect of Deprenyl on Behavioral Responses and Midbrain Dopamine Neurons in 6-Hydroxydopamine-Lesioned Rats Receiving Chronic Treatment of L-dopa. 1999 Parkinsonism and Related Disorder. 5 (suppl):88

Book

Hanafi Tanojo, Gena Y.Y. Chang, Jiun-Wen Guo, Xinfan Huang, and Howard I. Maibach : Role of Calcium in the Regulation of Skin Barrier Homeostasis. Edited by André O. Barel, Marc Paye, Howard I. Maibach. p.173-182. Boca Raton: CRC Press. 2009. Print ISBN: 978-1-4200-6963-1