PRINCIPLE INVESTIGATOR: Shih-Chang Lin, MD, PhD
(1) Director, Department of Internal Medicine, Cathay General Hospital, Taiwan
(2) Attending Physician and Chief, Division of Rheumatology and Immunology, Department of Internal Medicine, Cathay General Hospital, Taiwan
(3) Professor, School of Medicine, Fu Jen Catholic University, Taiwan
(1) PhD in Immunology and Virology, School of Biomedical Science, University of Massachusetts Medical Center, Massachusetts, USA.
(2) MS in Epidemiology, Harvard School of Public Health, Harvard University, Massachusetts, USA.
(3) MD, School of Medicine, Kaohsiung Medical University, Taiwan
Basic and clinical immunology; Rheumatology; Molecular and cellular biology; Epidemiology
The research in my laboratory is aimed at exploring the pathogenesis of various rheumatic autoimmune diseases and at identifying biomarkers for various autoimmune diseases, focusing on elucidating the pathogenesis of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). To understand the pathogenesis of SLE and RA, we have been analyzing the gene expression of immune-related genes at the transcript and protein levels in various peripheral blood immune cells and try to identify any dysregulation in the expression of immune-related genes in SLE and RA patients. the gene expression microarray analysis and proteomic techniques have also been employed to identify novel genes that may be aberrantly expressed in immune cells of SLE or in RA patients. Thus, dysregulated immune-related genes may be the potential candidate biomarkers of the disease diagnosis and activity evaluation for SLE and RA patients. Dysregulated genes also may contribute to the pathogenesis of SLE or RA and can be targets of designing the therapeutic treatment.
Office Address: Division of Rheumatology and Immunology, Department of Internal Medicine, 280 Jen-Ai Road, Section 4, Cathay General Hospital, Taipei
Phone : (02) 27082121 Ext. 3102
E mail: firstname.lastname@example.org