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Publications

  1. Tzu-Cheng Sung, Hsing-Fen Li, Akon Higuchi,* S. Suresh Kumar, Qing-Dong Ling, Yu-Wen Wu, Thierry Burnouf, Michiyo Nasu, Akihiro Umezawa, Kuei-Fang Lee, Han-Chow Wang, Yung Chang, Shih-Tien Hsu, Effect of cell culture biomaterials for completely xeno-free generation of human induced pluripotent stem cells, Biomaterials, 2020 Feb;230:119638.doi.org/10.1016/j.biomaterials.2019.119638.
  2. Yan Gao, Nien-Ju Ku, Tzu-Cheng Sung, Akon Higuchi,* Chi-Sheng Hung, Henry Hsin-chung Lee, Qing-Dong Ling, Nai-Chen Cheng, Akihiro Umezawae, Lassina Barro, Thierry Burnouf, Qingsong Ye and Hao Chen, The effect of human platelet lysate on the differentiation ability of human adipose-derived stem cells cultured on ECM-coated surfaces, J Mater Chem B., 7 (2019) 7110-7119.
  3. Tzu-Cheng Sung, Jia-Sin Yang, Chih-Chen Yeh, Ya-Chu Liu, Yi-Peng Jiang, Ming-Wei Lu, Qing-Dong Ling, S. Suresh Kumar, Yung Chang, Akihiro Umezawa, Hao Chen, Akon Higuchi,* The design of a thermoresponsive surface for the continuous culture of human pluripotent stem cells, Biomaterials, 221 (2019).
  4. Li-Hua Chen, Tzu-Cheng Sung, Henry Hsin-Chung Lee, Akon Higuchi,* Huan-Chiao Su, Kuan-Ju Lin, Yu-Ru Huang, Qing-Dong Ling, S. Suresh Kumar, Abdullah A. Alarfaj, Murugan A. Munusamy, Michiyo Nasu, Da-Chung Chen, Shih-Tien Hsu, Yung Chang, Kuei-Fang Lee, Han-Chow Wang, Akihiro Umezawa, Xeno-free and feeder-free culture and differentiation of human embryonic stem cells on recombinant vitronectin-grafted hydrogels, Biomaterials Science, 7(10) (2019) 4345-4362.
  5. A. Higuchi,* S.Suresh Kumar, Giovanni Benelli, Qing-Dong Ling*, Hsing-FenLi, Abdullah A.Alarfaj, Murugan A.Munusamy, Tzu-Cheng Sung, YungChang, Kadarkarai Murugan, Biomaterials Used in Stem Cell Therapy for Spinal Cord Injury, Prog. Mater Sci., 103 (2019) 374-424.
  6. Sung TC, Li HF, Higuchi A,* Ling QD, Yang JS, Tseng YC, Pan CP, Alarfaj AA, Munusamy MA, Kumar S, Hsu ST, Murugan K, Human Pluripotent Stem Cell Culture on Polyvinyl Alcohol-Co-Itaconic Acid Hydrogels with Varying Stiffness Under Xeno-Free Conditions, J Vis Exp. (JOVE) 2018, 132.
  7. Tsung-Hsuan Lai, Fung-Wei Chang, Jun-Jie Lin, Qing-Dong Ling*, Endometrial L-selectin ligand is downregulated in the mid-secretory phase during the menstrual cycle in women with adenomyosis. Taiwan J Obstet Gynecol. 2018 57(4):507-516.
  8. Tsung-Hsuan Lai, Fung-Wei Chang, Jun-Jie Lin, Qing-Dong Ling*, Gene expression of human endometrial L-selectin ligand in relation to the phases of the natural menstrual cycle. Scientific Reports. 2018, 8:1443-1457.
  9. Higuchi A, Ku NJ, Tseng YC, Pan CH, Li HF, Kumar SS, Ling QD*, Chang Y, Alarfaj AA, Munusamy MA, Benelli G, Murugan K. Stem cell therapies for myocardial infarction in clinical trials: bioengineering and biomaterial aspects. Laboratory Investigation. 2017 97(10):1167-1179 (SCI; IF=3.676). (Co-corresponding author)
  10. Saradaprasan Mudul, Henry Hsin-Chung Lee, Jia-Sin Yang, Ting-Yeh Chen,a Akon Higuchi, S. Suresh Kumar, Abdullah A. Alarfaj, Murugan A. Munusamy, Giovanni Benelli, Kadarkarai Murugan, Ching-Yuan Liu, Yi-Fan Chen, Yung Chang, Brintha Moorthy, Han-Chow Wang, Shih-Tien Hsul and Qing-Dong Ling. Proliferation and osteogenic differentiation of amniotic fluid-derived stem cells. Journal of Materials Chemistry B. Epub 2017 Jun 22.
  11. Chen YM, Chen LH, Li MP, Li HF, Higuchi A, Kumar SS, Ling QD, Alarfaj AA, Munusamy MA, Chang Y, Benelli G, Murugan K, Umezawa A. Xeno-free culture of human pluripotent stem cells on oligopeptide-grafted hydrogels with various molecular designs. Sci Rep. 2017. 7:45146.
  12. Peng IC, Yeh CC, Lu YT, Muduli S, Ling QD, Alarfaj AA, Munusamy MA, Kumar SS, Murugan K, Lee HC, Chang Y, Higuchi A. Continuous harvest of stem cells via partial detachment from thermoresponsive nanobrush surfaces. Biomaterials. 2016 Jan;76:76-86.
  13. Higuchi A, Kao SH, Ling QD, Chen YM, Li HF, Alarfaj AA, Munusamy MA, Murugan K, Chang SC, Lee HC, Hsu ST, Kumar SS, Umezawa A. Long-term xeno-free culture of human pluripotent stem cells on hydrogels with optimal elasticity. Sci Rep. 2015. 5:18136
  14. Jack Yu-Shih Lin, Chien Liang Wu, Chia Nan Liao, Akon Higuchi and Qing-Dong Ling*. Chemogenomic Analysis of Neuronal Differentiation with Pathway Changes in PC12 Cells. Molecular Biosystems. 2016. 12(1):283-94. (SCI; IF=2.781).
  15. Akon Higuchi,* Qing-Dong Ling,* S. Suresh Kumar, Yung Chang, Abdullah A. Alarfaj, Murugan A. Munusamy, Kadarkarai Murugan, Shih-Tien Hsui and Akihiro Umezawa. Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells. Journal of Materials Chemistry B. 2015. 3(41): 8032-58. (SCI; IF=4.543) (Co-corresponding author).
  16. Higuchi A, Wang CT, Ling QD, Lee HH, Kumar SS, Chang Y, Alarfaj AA, Munusamy MA, Hsu ST, Wu GJ, Umezawa A.A hybrid-membrane migration method to isolate high-purity adipose-derived stem cells from fat tissues. Sci Rep. 2015. 5:10217.
  17. Akon Higuchi, Qing-Dong Ling, S Suresh Kumar, Murugan A Munusamy, Abdullah A Alarfaj, Yung Chang, Shih-Hsuan Kao, Ke-Chen Lin, Han-Chow Wang and Akihiro Umezawa. Generation of pluripotent stem cells without the use of genetic material. Laboratory Investigation. 2015 95(1): 26-42. (SCI; IF=3.676).
  18. Akon Higuchi, Qing-Dong Ling, S. Suresh Kumar, Yung Chang, Ta-Chun Kao, Murugan Munusamy, Abdullah A. Alarfajj, Shih-Tien Hsu, Akihiro Umezawa. External stimulus-responsive biomaterials designed for the culture and differentiation of ES, iPS, and adult stem cells. Prog Polym Sci. 2014. 39: 1585–1613 (SCI; IF=25.766).
  19. Akon Higuchi, Qing-Dong Ling, S. Suresh Kumar, Murugan Munusamy, Abdullah A. Alarfajj, Akihiro Umezawa, Gwo-Jang Wu. Design of polymeric materials for culturing human pluripotent stem cells: Progress toward feeder-free and xeno-free culturing. Prog Polym Sci. 2014. 39: 1348–1374 (SCI; IF=25.766).
  20. Chen DC, Chen LY, Ling QD, Wu MH, Wang CT, Kumar SS, Chang Y, Munusamy M, Alarfajj AA, Wang HC, Hsu ST, Higuchi A. Purification of human adipose-derived stem cells from fat tissues using PLGA/silk screen hybrid membranes. Biomaterials. 2014 35(14):4278-87.
  21. Akon Higuchi, Feng-ling Lin, Yu-Kai Cheng, Ta-Chun Kao, S. Suresh Kumar, Qing-Dong Ling, Chun-Han Hou, Da-Chung Chen, Shih-Tien Hsu and Gwo-Jang Wu. Preparation of induced pluripotent stem cells on dishes grafted on oligopeptide under feeder-free conditions. Journal of the Taiwan Institute of Chemical Engineers. 2014 45: 295-301.
  22. Kumar SS, Hsiao JH, Ling QD, Dulinska-Molak I, Chen G, Chang Y, Chang Y, Chen YH, Chen DC, Hsu ST, Higuchi A. The combined influence of substrate elasticity and surface-grafted molecules on the ex vivo expansion of hematopoietic stem and progenitor cells. Biomaterials. 2013: 34(31):7632-44.
  23. Kao TC, Lee HH, Higuchi A, Ling QD*, Yu WC, Chou YH, Wang PY, Kumar SS, Chang Y, Chen YH, Chang Y, Chen DC, Hsu ST. Suppression of cancer-initiating cells and selection of adipose-derived stem cells cultured on biomaterials having specific nanosegments. J Biomed Mater Res Part B 2014: 102(3):463-76 (SCI; IF=3.189) (Co-corresponding author).
  24. Lee HH, Ling QD, Hung CM, Kao TC, Huang YW, Higuchi A. Drug-resistant colon cancer cells produce high carcinoembryonic antigen and might not be cancer-initiating cells. Drug Design, Development and Therapy. 2013; 7:491-502.
  25. Akon Higuchi, Qing-Dong Ling, Yong Chang, Shih-Tien Hsu, and Akihiro Umezawa. Physical Cues of Biomaterials Guide Stem Cell Differentiation Fate. Chemical Reviews. 2013; 113(5):3297-328 (SCI; IF=47.928).
  26. Cheng-Han Wu, Fa-Kung Lee, S. Suresh Kumar, Qing-Dong Ling,*, Yung Change, Yu Changf, Han-Chow Wangg, Hui Chena, Da-Chung Chenh, Shih-Tien Hsuh, Akon Higuchi*, The Isolation and Differentiation of Human Adipose-Derived Stem Cells Using Membrane Filtration. Biomaterials. 2012 33(33):8228-39 (SCI; IF=8.402). (Co-corresponding author).
  27. Akon Higuchi, Qing-Dong Ling, Shih-Tien Hsu, and Akihiro Umezawa. Biomimetic Cell Culture Proteins as Extracellular Matrices for Stem Cell Differentiation. Chemical Reviews. 2012; 112(8):4507-40 (SCI; IF=47.928).
  28. Li-Ying Chen, Yung Chang, Jui-Shiang Shiao, Qing-Dong Ling, Yu Chang, Yung Hung Chen, Da-Chung Chen, Shih-Tien Hsu, Henry Hsin-chung Lee and Akon Higuchi, Effect of the surface density of nanosegments immobilized on culture dishes on ex vivo expansion of hematopoietic stem and progenitor cells from umbilical cord blood. Acta Biomater. 2012; 8(5):1749-58.
  29. Chih-Hao Chen, Hsing-Chung Lee, Qingdong Ling, Hsiao-Rong Chen1, Yi-An Ko1, Tsong-Shan Tsou, Sun-Chong Wang, Li-Ching Wu1 and H. C. Lee, An all-statistics, high-speed algorithm for the analysis of copy number variation in genomes. Nucleic Acids Research, 2011, 1–7.
  30. Higuchi A, Shen PY, Zhao JK, Chen CW, Ling QD, Chen H, Wang HC, Bing JT, Hsu ST. Osteoblast Differentiation of Amniotic Fluid-Derived Stem Cells Irradiated with Visible Light. Tissue Eng Part A. 17(21-22):2593-602, 2011.
  31. Akon Higuchi, Qing-Dong Ling, Yi-An Ko, Yung Chang and Akihiro Umezawa, Biomaterials for the feeder-free culture of human embryonic stem cells and induced pluripotent stem cells. Chemical Reviews. 2011; 111(5):3021-35 (SCI; IF=47.928).
  32. Qing-Dong Ling, Ling-Yi Ho, Yi-An Ko, Yung Chang, Akon Higuchi, Visible Light Regulated Gene Expression and Neurite Outgrowth of Nerve Cells, J. Chem. Eng. Japan, 2011,  44: 171-178 (SCI)
  33. Lung-Huang Lin, Cheng-Yuan Tsai, Min-Hsuan Hung, Yu-Ti Fang and Qing-Dong Ling*, Rectal Swab Sampling Following an Enriched Culture Based real-time PCR Assay to Detect Salmonella Enterocolitis in Children. Clinical Microbiology and Infection. (2011) 17(9):1421-5 (SCI; IF=5.292).
  34. Jack Yu-Shih Lin, Yu-Che Cheng, Julia Yi-Ru Chen, Chih-Cheng Chien, Shih-Chang Lin, Yeong-Ray Wen, Tsung-Shan Tsou and Qing-Dong Ling*, Increased Spinal Prodynorphin Gene Expression in re-inflammation-associated-hyperalgesia after Neonatal Peripheral Inflammatory Insult. BMC neuroscience. 11(1): 139-147. 2010 (SCI; IF=3.091).
  35. Higuchi A, Ling-Yi H, Huang LY, Chen H, Chen YJ, Ling QD, Measurements of movement and diffusion coefficients of single cells on polymeric surface from image analysis. J Biomater Sci Polym Ed. 2010;21(12):1545-58.
  36. Chang, Yung; Yandi, Wetra; Chen, Wen-Yih; Shih, Yu-Ju; Yang, Chang-Chung; Chang, Yu; Ling, Qing-Dong; Higuchi, Akon, Tunable-Bioadhesive Copolymer Hydrogels of Thermoresponsive Poly(N-isopropyl acrylamide) Containing Zwitterionic Polysulfobetaine, Biomacromolecules, 11(4), (2010) 1101-1110 (SCI; IF=5.75).
  37. Akon Higuchi, Siou-Ting Yang, Pei-Tsz Li, Miho Tamai, Yoh-ichi Tagawa, Yung Chang, Yu Chang, Qing-Dong Ling and Shih-Tien Hsu, Direct ex vivo expansion of hematopoietic stem cells from umbilical cord blood on membranes..J. Membrane Sci. 351 (2010) 104-111.
  38. Akon Higuchi, Miho Tamai, Yi-An Ko, Yoh-ichi Tagawa Yuan-Hsuan Wu, Benny D. Freeman,Jun-Tang Bing, Yung Chang, and Qing-Dong Ling, Polymeric Membranes for Chiral Separation of Pharmaceuticals and Chemicals. Polymer Reviews. 2010; 50(2):113-143 (SCI; IF=7.79).
  39. Huang HI, Chen SK, Ling QD, Chien CC, Liu HT, Chan SH. Multilineage Differentiation Potential of Fibroblast-Like Stromal Cells Derived from Human Skin. Tissue Eng Part A. 2010 May 16(5): 1491-1501.
  40. P-C Kuo, J-Y-S Lin, L-C Chen, Y-T Fang, Y-C Cheng, H-Y Wu, C-Y Tsai, Y-S Chen, S-Y Lin, C-L Wu and Q-D Ling*. Molecular and immunocytochemical identification of coxsackievirus A-24 variant from the acute haemorrhagic conjunctivitis outbreak in Taiwan in 2007. Eye. 2010; 24(1):131-6 (SCI; IF=2.082).
  41. Akon Higuchi, Miho Tamai, Yoh-ichi Tagawa, Yung Chang, Qing-Dong Ling, Surface Modification of Polymeric Membranes for Low Protein binding, Membrane Water Treatment, 1(2), 103-120 (2010).
  42. Wei CF, She BC, Liang HS, Ling QD, Tsai CY, Yen CW, Wu HY, Tsai MS. Prenatal Group B Streptococcus test using real-time polymerase chain reaction. Taiwan J Obstet Gynecol. 2009 Jun; 48 (2):116-9.
  43. A. Higuchi, S.-T. Yang, P.-T. Li, R.-C. Ruaan, W.-Y. Chen, Y. Chang, Y. Chang, E. M. Tsai, Y. H. Chen, H.-C.Wang and S.-Ti. Hsu, Q.-D. Ling, Permeation of blood cells from umbilical cord blood through surface-modified polyurethane foaming membranes, J. Membrane Sci. 339 (2009) 184-188.
  44. Akon Higuchi, Siou-Ting Yang, Pei-Tsz Li, Hui Chen, Ruoh-chyu Ruaan, Wen-Yih Chen, Yung Chang, Yu Chang, Eing Mei Tsai, Qing-Dong Ling, Han-Chow Wang and Shih-Tien Hsu, Separation of hematopoietic stem and progenitor cells from human peripheral blood through polyurethane foaming membranes modified with several amino acids, J. Appl. Polym. Sci., 114(2), 671-679 (2009).
  45. Hsiao-Lun Sun, Yu-Che Cheng, Shu-Lin Guo, Jann-Inn Tzeng, Chih-Cheng Chien, Liang-Hui Chien and Qing-Dong Ling*. Identification of genes expression in spinal cord after peripheral inflammation using DNA microarray techniques. Chinese J. Pain. 2008; 18(1): 15-24.
  46. Lin SC, Chen KH, Lin CH, Kuo CC, Ling QD, Chan CH. The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients. Eur J Clin Invest. 2007 Dec; 37(12):987-96.
  47. Yeong-Ray Wen; Geng-Chang Yeh; Bai-Chuang Shyu; Qing-Dong Ling; Kuo-Ching Wang; Ta-Liang Chen; Wei-Zen Sun, A minimal stress model for the assessment of electroacupuncture analgesia in rats under halothane. Eur. J. Pain. 2007 Oct; 11 (7):733-42.
  48. Chih-Cheng Chien, Wen Mei Fu, Yuan-Wen Lee, Yu-fang Chan, Yeur-Hur Lai and Qing Dong Ling*, Expression of neurotrophic factors in neonatal rats after peripheral inflammation. J Pain. 2007, 8(2), 161-167 (SCI; IF=5.445).
  49. Chia-Huei Lee, Qing-Dong Ling, and Mei-Hwei Chang. Characterization of De Novo Genomic Alterations in HBV-Producing Hepatoma Cells Using Array Comparative Genomic Hybridization. J. Cancer Molecule 28(5): 261-6. 2005
  50. Jeng CJ, Ko ML, Ling QD, Shen J, Lin HW, Tzeng CR, Ho CM, Chien TY, Chen SC. Prevalence of Cervical Human Papillomavirus in Taiwanese Women. Clin Invest Med. 28(5): 261-6. 2005.
  51. Hui-Wen Lin, Cherng-Jye Jeng, Su-Chee Chen, Chih-Chien Cheng, Horng-Shuoh Liang and Qing-Dong Ling*: Development of a Molecular Detection Procedure for a PCR-Based HPV Genotyping DNA Chip. Fu Jen Journal of Medicine Vol.2 Suppl. 2004; S171-S176.
  52. Fu WM, Chang TK, Sun WZ, Ling QD, Peng HC, Liou HC, Lu DY, Huang TF. Inhibition of neuropathic pain by a potent disintegrin--triflavin. Neurosci Lett. 368(3):263-268. 2004.
  53. Hsiao Lun Sun, Qing Dong Ling, Wei Zen Sun, Rick Sai-Chuen Wu, Tzong Jeng Wu, Shih Chieh Wang, Chih Cheng Chien: Lower Limb Wrapping Prevents Hypotension, but not Hypothermia or Shivering after Introduction of Epidural Anesthesia for Cesarean Section. Anesth Analg. 99(1):241-244. 2004.
  54. Ling, Q.D., Chien C.C., Wen, Y. R., Fu, W.M., Sun, W.Z.. (2003). The pattern and distribution of calcitonin gene-related peptide (CGRP) terminals in the rat dorsal following neonatal peripheral inflammation. NeuroReport, 14(15):1919-1921. 2003. (SCI; IF=1.52)
  55. Wen-Jeng Wang, Qing-Dong Ling, Ming-Yi Liau, and Tur-Fu Huang. A tetrameric glycoprotein Ib-binding protein, agglucetin, from Formosan pit viper: structure and interaction with human platelets. Thromb Haemost. 90(3):465-75. 2003 (SCI; IF=5.627)
  56. Yuan Bo Peng, Qing Dong Ling, M. A. Ruda and Daniel R. Kenshalo: Electrophysiological changes in adult rat dorsal horn neurons after neonatal peripheral inflammation. J Neurophysiol. 90(1):73-80. 2003 (SCI; IF=3.32)
  57. R.S. Yang, C.H. Tang, Q.D. Ling, S.H. Liu and W.M. Fu: Regulation of fibronectin fibrillogenesis by protein kinases in cultured rat osteoblasts. Mol Pharmacol. 61(5):1163-73, 2002. (SCI; IF=4.44)
  58. T. Tachibana, Q.D. Ling and M. A. Ruda: Increased Fos Induction in Adult Rats that Experienced Neonatal Peripheral Inflammation. Neuroreport. 12(5):925-7. 2001.
  59. M.A. Ruda, Q.D. Ling, A.G. Hohmann, Y.B. Peng, T. Tachibana: Altered Nociceptive Neuronal Circuits After Neonatal Peripheral Inflammation. Science. 289(5479): 628-631, 2000. (SCI; IF=37.21)
  60. H. Bradshaw, J. Miller, Q.D. Ling, K. Malsnee, M.A. Ruda, Sex differences and phases of the estrous cycle alter the response of spinal cord dynorphin neurons to peripheral inflammation and hyperalgesia. Pain. 85(1-2):93-99, 2000.
  61. QD, Ling, H, Noma, et. all: An electron microscopic study on lyophilized nerve allografting – Nerve regeneration accompanying the disintegration of the Schwann cell basal laminia-. The Shikawa Gakuho, 97: 379-384 1997.
  62. QD, Ling, H, Noma: An experimental study of allografting lyophilized nerves in the rabbit great auricular nerve – Allografting for long-distance nerve defects-. Jpn. J. Oral Maxillofac. Surg., 43(1): 16-32 1997.

Books

  1. 凌慶東: 齒槽神經麻痺, Chapter 15-IV, シュワン細胞、神經周膜の役割. 日本醫齒藥出版株式會社 2001
  2. Qing-Dong Ling, Jack Yu-Shih Lin and Chih-Cheng Chien. The influence of neonatal and infantile pain experience on neuronal growth and development. Nociceptive and Neuropathic Pain: Mechanisms and Treatments, 2009: 93-104 ISBN: 978-81-308-0368-5 Editors: Bai-Chuang Shyu and Chih-Cheng Chien

更新時間：2023/7/13