部主任:林世昌 

部主任:林世昌


現職:
國泰綜合醫院內科部部長
國泰綜合醫院內科部風濕科主任
國泰綜合醫院老人醫學科主任
輔仁大學醫學系專任部定教授

代碼 01462

人氣 4244





醫務專長

  • 風濕疾病之診治
  • 過敏免疫疾病之診治
  • 過敏免疫疾病之檢測
  • 風濕免疫學研究
  • 基礎免疫學研究
  • 流行病學研究
  • 分子生物學研究

學歷

  • 美國麻州州立大學(University of Massachusetts Medical Center) 免疫學博士
  • 美國哈佛(Harvard University)大學流行病學碩士
  • 高雄醫學大學醫學系畢業

經歷

  • 美國哈佛大學麻州總醫院病理科免疫學研究員
  • 美國麻州州立大學醫學中心微生物科免疫學博士後研究
  • 高雄醫學大學附設醫院過敏免疫風濕科總醫師
  • 高雄醫學大學附設醫院內科住院醫師
  • 高雄醫學大學微生物學科兼任助理教授
  • 輔仁大學醫學系專任副教授教授
  • 台北醫學大學醫學系兼任副教授
  • 中央大學兼任副教授
  • 國泰綜合醫院過敏免疫學科主任
  • 國泰綜合醫院醫學研究部部長
  • 分子醫學會理事
  • 免疫學會秘書長

論文及學術著作

  • Chun‐Ta Huang CT, Chen SH, Lin SC, Chen WT, Lue JH, Tsai YJ. (2018) Erythropoietin reduces nerve demyelination, neuropathic pain behavior and microglial MAPKs activation through erythropoietin receptors on Schwann cells in a rat model of peripheral neuropathy. Glia, in press. (SCI)
  • Madda R, Lin SC (co-first author), Sun WH, Huang SL. (2018) Differential expressions of plasma proteins in systemic lupus erythematosus patients identified by proteomic analysis. Journal of Microbiology, Immunology, and Infection, in press. (SCI)
  • Madda R, Lin SC, Sun WH, Huang SL. (2018) Plasma proteomic analysis of systemic lupus erythematosus patients using liquid chromatography/tandem mass spectrometry with label-free quantification. PeerJ. 8;6:e4730. (SCI)
  • Yu KH, Chen DY, Chen JH, Chen SY, Chen SM, Cheng TT, Hsieh SC, Hsieh TY, Hsu PF, Kuo CF, Kuo MC, Lam HC, Lee IT, Liang TH, Lin HY, Lin SC, Tsai WP, Tsay GJ, Wei JC, Yang CH, Tsai WC. (2018) Management of gout and hyperuricemia: Multidisciplinary consensus in Taiwan. International Journal of Rheumatic Diseases. 21(4):772-787. (SCI)
  • 林世昌(Lin SC) (2018) 綜論生物製劑免疫療法在非癌症之應用 Formosan Journal of Medicine(台灣醫學) 22(4): 380-387.
  • Lin YL, Lin SC (corresponding). (2017) Analysis of the CD161-expressing cell quantities and CD161 expression levels in peripheral blood natural killer and T cells of systemic lupus erythematosus patients. Clinical and Experimental Medicine, 17(1):101-109. (SCI)
  • Lu WJ, Lin SC (co-first author), Lan CC, Lee TY, Hsia CH, Huang YK, Lee HC, Sheu JR. (2014) Effect of Antrodia camphorata in inflammatory arterial thrombosis-mediated platelet activation: The pivotal role of protein kinase C. Scientific World Journal, 2014:745802. (SCI)
  • Hu JT, Ho CP, Huang YW, Lin SC (corresponding). (2014) The analysis of T cell anergy in patients with chronic hepatitis C virus infection. Clinical Molecular Medicine, 5(1):3-6. (SCI)
  • Jayakumar T, Chang CC, Lin SL, Huang YK, Hu CM, Elizebeth AR, Lin SC (co-corresponding), Choy CS. (2014) Brazilin ameliorates high glucose-induced vascular inflammation via inhibiting ROS and CAMs production in human umbilical vein endothelial cells. BioMed Research International (Journal of Biomedicine and Biotechnology). 19(7):637-643. (SCI)
  • Huang YW, Hsu CK, Lin SC, Wei SC, Hu JT, Chang HY, Liang CW, Chen DS, Chen PJ, Hsu PN, Yang SS, Kao JH. (2014) Reduced Toll-like receptor-9 expression on peripheral CD14+ monocytes of chronic hepatitis B patients and its restoration by effective therapy. Antiviral Therapy. 19(7):637-643. (SCI)
  • Huang YW, Wang TC, Lin SC, Chang HY, Chen DS, Hu JT, Yang SS, Kao JH. (2013) Increased risk of cirrhosis and its decompensation in chronic hepatitis B patients with newly diagnosed diabetes: a nationwide cohort study. Clinical Infectious Diseases, 57(12): 1695-1702. (SCI)
  • Cornejo-García JA, Liou LB, Blanca-López N, Doña I, Chen CH, Chou YC, Chuang HP, Wu JY, Chen YT, Plaza-Serón Mdel C, Mayorga C, Guéant-Rodríguez RM, Lin SC, Torres MJ, Campo P, Rondón C, Laguna JJ, Fernández J, Guéant JL, Canto G, Blanca M, Lee MT. (2013) Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations. Pharmacogenomics, 14(15): 1857-1869. (SCI)
  • Lin SC, Tsai YJ, Huang CT, Kuo YW, Ruan SY, Chuang YC, Yu CJ. (2013) Prognostic value of plasma N-terminal pro B-type natriuretic peptide levels in pneumonia patients requiring intensive care unit admission. Respirology, 18(6):933-941. (SCI)
  • Huang YW, Lin SC, Wei SC, Hu JT, Chang HY, Huang SH, Chen DS, Chen PJ, Hsu PN, Yang SS, Kao JH. (2013) Reduced Toll-like receptor 3 expression in chronic hepatitis B patients and its restoration by interferon therapy. Antiviral Therapy, 18(7): 877-884. (SCI)
  • Shen CM, Lin SC, Niu DM, Kou YR. (2013) Development of monocyte Toll-like receptor 2 and Toll-like receptor 4 in preterm newborns during the first few months of life. Pediatric Research, 73(5):685-691. (SCI)
  • Lin SC. (2013) Update on the treatment of rheumatoid arthritis with immune biological agents. Formosan Journal of Medicine, 17(1): 30-33.
  • Chen KH, Lin SC (corresponding). (2012) The inflammasome activation in immune responses and human diseases. Clinical and Molecular Medicine, 3(2): 7-9.
  • 林世昌(Lin SC) 風濕病學(第二版): 第24章 抗磷脂抗體症候群(合記圖書出版社ISBN:9789861267913)
  • Tsao JT, Hsieh SC, Chiang BL, Yu CL, Lin SC (corresponding). (2012) Altered IL-10 and TNF-α production in peripheral blood mononuclear cells of systemic lupus erythematosus patients after Toll-like receptor 2, 4, or 9 activation. Clinical and Experimental Medicine, 12(3):153-158.
  • Jin SL, Ding SL, Lin SC (corresponding). (2012) Phosphodiesterase 4 and its inhibitors in inflammatory diseases. Chang Gung Medical Journal (Biomedical Journal), 35(3):197-210.
  • Tsai YJ, Huang CT, Lin SC, Yeh JH. (2012) Effects of regional and whole-body hypothermic treatment before and after median nerve injury on neuropathic pain and glial activation in rat cuneate nucleus. Anesthesiology, 116(2):415-431.
  • Lin SC (corresponding), Kuo CC, Tsao JT, Lin LJ. (2012) Profiling the expression of interleukin (IL)-28 and IL-28 receptor α in systemic lupus erythematosus patients. European Journal of Clinical Investigation, 42(1):61-69.
  • 李嘉鐸;吳哲輝;林宏政;莊世昌;林世昌 (2011) 疑似對局部麻醉劑過敏病史之處置及病例報告(Management of allergy-like reaction history to local anesthetics: report of two cases) 臺灣口腔顎面外科學會雜誌, 22(2):150-155.
  • Lin SC, Yeh JH, Chen CL, Chou SH, Tsai YJ. (2011) Effects of local lidocaine treatment before and after median nerve injury on mechanical hypersensitivity and microglia activation in rat cuneate nucleus. European Journal of Pain. 15(4):359-367.
  • Chou CT, Tsai CY, Liang TH, Chang TM, Lai CH, Wei CC, Chen KH, Lin SC, Yu CL, Liou LB, Luo SF, Lee CS, Hsue YT, Huang CM, Chen JH, Lai NS, Cheng HH, Cheng TT, Lai HM, Tsai WC, Yen JH, Lu LY, Chang CP. (2010) Better short-term clinical response to etanercept in Chinese than Caucasian patients with active ankylosing spondylitis. Modern Rheumatology, 20(6):580-587.
  • Lin JY, Cheng YC, Chen JY, Chien CC, Lin SC, Wen YR, Tsou TS, Ling QD. (2010) Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult. BMC Neurosciences, 11: 139.
  • Tsao JT, Yu CL, Hsieh SC, She TW, Kuo CC, Lin SC (corresponding). (2009) CpG ODN ligation of TLR-9 attenuate TNF-α production in untreated active SLE patients. Formosan Journal of Rheumatology, 23(2): 59-65.
  • Shen CM, Lin SC, Niu DM, Kou YR. (2009) Labour increases the surface expression of two Toll-like receptors in the cord blood monocytes of healthy term newborns. Acta Paediatrica, 98(6): 959-962.
  • Lin SC (corresponding), Kuo CC. (2009) Lack of the Association of a BTLA gene polymorphism with the susceptibility to systemic lupus erythematosus in Taiwan. Clinical Molecular Medicine, 1(2): 28-32.
  • Tsao JT, Kuo CC, Lin SC(corresponding). (2008) The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients, Clinical Experimental Medicine, 8(4):179-85. (SCI)
  • Huang CJ, Chien CC, Yang SH, Chang CC, Sun HL, Cheng YC, Liu CC, Lin SC, Lin CM (2008) Faecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. Journal of cellular and molecular medicine, 12(5B):1936-43. (SCI)
  • Lin SC (corresponding), Chen KH, Lin CH, Kuo CC, Lin QD, Chan CH. (2007) The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients. European Journal of Clinical Investigation, 37(12):987-96. (SCI)
  • Kuo CC and Lin SC (corresponding). (2007) Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Molecular Medicine, 13(11-12):561-6. (SCI)
  • Lin SC (corresponding), Kuo CC, Chan CH. (2006) Association of a BTLA gene polymorphism with the risk of rheumatoid arthritis. J Biomed Sci. 13(6):853-860. (SCI)
  • Lin SC. (2006) Identification of an NF-Y/HMG-I(Y)-binding site in the human IL-10 promoter. Molecular Immunology, 43: 1325-1331 (SCI)
  • Lin SC and Chen CJ. (2005) Letter: reply to “Programmed death 1 gene polymorphism and systemic lupus erythematosus in different ethnic populations: comment on the article by Lin et al”. Arthritis and Rheumatism, 52 (1): 363-364. (SCI)
  • Chen CJ, Lin KH, Lin SC, Tsai WC, Yen JH, Chang SJ, Lu SN, and Liu HW. (2005) High Prevalence of IgA antibody against Epstein-Barr Virus viral capsid antigen in adult lupus patients with disease flare: case-control studies. J of Rheumatology, 32(1): 44-47. (SCI)
  • Lin SC, Yen JH, Tsai WC, Ou TT, Tsai JJ, Chen CJ, Liu HW. A Program Death-1 Gene Polymorphism is Associated with the Development of Rheumatoid Arthritis, but not Systemic Lupus Erythematosus. Arthritis Rheum, 50(3): 770-775. (SCI)
  • Chen KH, Lin SC, Ma SM, Chung MH, Gonn ST. (2004) Renal tubular dysfunction with hypokalemic paralysis in primary Sjögren’s Syndrome: a case report and the literature review. Fu Jen J of Med, 2004; 2 (suppl): s119-s126
  • Hsieh CW, Lin SC, Chen KH, Tsai JJ. Impaired monocyte oxidative burst activity in HLA-B27-positive ankylosing spondylitis patients. J of Rheum ROC. 2003, 17(1-2); 31-43.
  • Hsieh CW, Chen KH, Wu MH, Lin SC, Tsai JJ. Hydroxychloroquine related irreversible hearing loss in a patient of rheumatoid arthritis. J of Rheum ROC. 2003,17(1-2); 55-61.
  • Yang WC, Lin SC, Liu TC, Chen CJ, Yen JH, Ou TT, Liu HW, Tsai WC. Clubbed fingers and hypertrophic osteoarthropathy in a patient with squamous cell carcinoma of the lung. Kaohsiung J Med Sci. 2003, 19 (4): 183-187.
  • Yen JH, Chen CJ, Tsai WC, Lin CH, Ou TT, Lin SC, Liu HW. Tumor necrosis factor microsatellite alleles in patients with rheumatoid arthritis in Taiwan. Immunol Lett. 2002; 81(3): 177-82. (SCI)
  • Yen JH, Tsai WC, Ou TT, Lin SC, Chen CJ, Liu HW. Systemic lupus erythematosus complicated by recurrent spontaneous pneumothorax--a case report. Kaohsiung J Med Sci. 2001;17(10): 540-544.
  • Yen JH, Chen CJ, Tsai WC, Ou TT, Lin CH, Lin SC, Liu HW. HLA-DQA1 genotyping in patients with rheumatoid arthritis in Taiwan. Kaohsiung J Med Sci. 2001 Apr.; 17(4), 183-188.
  • Lin SC, Wortis HH ,Stavnezer J. The ability of CD40L, but not lipopolysaccharide, to initiate immunoglobulin switching to immunoglobulin G1 is explained by differential induction of NF-kB/Rel proteins. Mol Cell Biol. 1998 Sep; 18(9): 5523- 5532. (SCI)
  • Lin SC. The ability of CD40L, but not LPS, to induce germline immunoglobulin g1 transcripts is explained by differential induction of NF-kB/Rel proteins. A Ph.D Dissertation at University Massachusetts Medical Center, 1998 Jan.
  • Lin SC, Stavnezer J. Activation of NF-kB/Rel by CD40 engagement induces the mouse germ line immunoglobulin Cg1 promoter. Mol Cell Biol. 1996 Sep;16(9): 4591-4603. (SCI)
  • Guo YJ, Wong JH, Lin SC, Aruffo A, Stamenkovic I, Sy MS. Disruption of T lymphocyte reappearance in anti-Thy-1-treated animals in vivo with soluble CD44 and L-selectin molecules. Cell Immunol. 1994 Mar; 154(1): 202-218. (SCI)
  • Guo YJ, Lin SC, Wang JH, Bigby M, Sy MS. Palmitoylation of CD44 interferes with CD3-mediated signaling in human T lymphocytes. Int Immunol. 1994 Feb; 6(2): 213-221. (SCI)
  • Guo YJ, Ma J, Wang JH, Lin SC, Chang HC, Bigby M, Sy MS. Monoclonal anti-CD44 antibody acts in synergy with anti-CD2 but inhibits anti-CD3 or T cell receptor-mediated signaling in murine T cell hybridomas. Cell Immunol. 1993 Nov; 152(1): 186-199. (SCI)

資料更新日期:2020/6/19

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部主任:林世昌

現職:
國泰綜合醫院內科部部長
國泰綜合醫院內科部風濕科主任
國泰綜合醫院老人醫學科主任
輔仁大學醫學系專任部定教授

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